Dear all,
I am working on the CLL cell line entitled "183-E95." After incubation of these cells with mAb anti-CD95 I observed high level expression of CD95. But, I am sure that my cells are totally alive and not undergone apoptosis. This state even seen in control groups. Thanks for any helpful comments.
Kind Reagrads
Alireza Goodarzi
Hi,
The excess of CD95L secreted by tumor cells may drive EMT and stemness and render tumor cells more motile and invasive, it is not clear whether targeting this secreted protein will be enough to block the tumor-promoting activities of CD95 and CD95L.
I recommend you to read this publication
http://www.nature.com/cdd/journal/v22/n4/full/cdd20153a.html
Good luck,
Hi Manel,
many thanks for your nice comments.
Hope all the best for you during working for scientific investigations:)
Kind Regards
Alireza Goodarzi
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