Hi, I am looking for a IP HPLC method for Patisiran siRNA or in general any siRNA would be helpful. Any paper suggestion would work?

27 January 2025 0 7K Report

Currently, I tried with siRNA using mobile phase A: 100mM TEAA+ Acetonitrile (20:80) and mobile phase B: 100mM TEAA+ Acetonitrile (95:5). But the RT keeps changing and baseline is not straight.

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