I think you need to choose grade 3, as in hypoxia ANGPTL4 disrupts endothelial cell junctions by directly interacting with integrin, VE-cadherin and claudin-5 ( in the study of tumor processes in breast cancer patients), that suggests that ANGPTL4 is a critical regulator of macrophage functions.
Grade 2 will not give a full understanding of an important role ANGPTL4 in numerous cancers and is implicated in the metastatic process by modulating vascular permeability, cancer cell motility and invasiveness in hypoxia.