I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the max concentration?
The same question about solubility in ethanol.
Thank you!
You may do a general check up, but it is best do look at the data to make sure it is. To question the solubility of the substance, you normally look at the chain, depending on what it contains, you might expect to be soluble, however it is relative on both ways. You normally say it is soluble on something, but it only depends if you compare it with the substance to be disolved. The structure and the components of the chain may give an idea of how soluble it is. If it has cooh, ch3, and so on. The longer the chain, the less soluble. The shorter the better. The viscosity gives a general view if it may dissolve. A high viscosity, the less soluble. Maybe you could check these parameters from your provider. I do know there are standards which tells if the substances may dissolve or not. (It is a number given, what I don't know if in this number the density could be included. There are lists of numbers). The nature of the substance does help. Polar, organic, etc. An organic substance dissolves in an organic substance. If it is organic it won't dissolve. If it is polar and organic, it won't either. (Substances that are alike). Apolar and apolar. And of course you may get it is more soluble than... And is soluble compared to... Where density and viscosity are included. Those parameters affect the solubility, and as I say there are lists of numbers. Chemists have been collecting lists of solubility values for years. What I don't know if it is more proper and not property based. The provider might explain the nature of the substance.
This drug is insoluble in ethanol or water. https://www.selleckchem.com/products/napabucasin.html
It's best to dilute to a very high concentration in DMSO (apparently 14 mg/mL; 58.28 mM). Then make smaller dilutions with aliquots of which ever solvent you want to use (including water). If not soluble, you can always go back and get a concentrated stock solution in DMSO. SellectChem also suggests using the following dilution scheme:
Please see reference. Reconstitute one after the other, in this order.
5% DMSO+40% PEG300+5% Tween 80+ddH2O - You can buy the latter from the vendor.
Oscar, what about this information?
https://www.caymanchem.com/pdfs/22255.pdf
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