Your mutant mice develop type 1 diabetes mellitus or type 2?

If you go through the literature, you will find that all the reasons you listed, and some additional ones, could play a role in influencing blood glucose levels.

Asking others for opinions without defining the strain of mice (or the mutation) is practically an exercise in futility.

Best,

Dear Barnabe,

We haven't really looked in to that detail.

Best regards,

Abhijit

Dear Tausif,

Thanks a lot for your views on this. I understand that it is difficult to give an opinion without knowing details, but my intention was just to have a very general idea from other researchers and not really specific to my mice. Going through literature is certainly needed, but what I feel personally is that on RG scientists interact directly and it is more faster way to get information as well as different opinions on the topic of interest.

Thanks again.

Best regards,

Abhijit 

"Going through literature is certainly needed, but what I feel personally is that on RG scientists interact directly and it is more faster way to get information as well as different opinions on the topic of interest."

Information on what?

What would be the point of opinions which to you will be no more than random ramblings when you have not decided or reviewed anything yourself?

Begin with literature survey and see what interests you.

Best,

In the case of type 1 diabetes mellitus, the beta cells are destroyed, causing a lack of insulin which requires external input. In the case of type 2 diabetes mellitus, events are more complex and may include insulin resistance, obesity, hypertention (...).

It is necessary to create an experimental model of diabetes mellitus taking into account the different parameters. But most importatnt is the induction of a very high fasting blood glucose level.