I have given a bolus (drink containing sugar) and measured HOMA and QUICKI indexes post-bolus for up to 5hrs every hour.
I know both HOMA and QUICKI work on fasting insulin and glucose values, does this mean my data is invalid as I have given my participants a drink to consume?
HOMA is a model of the relationship of glucose and insulin dynamics that predicts fasting steady-state glucose and insulin concentrations for a wide range of possible combinations of insulin resistance and β-cell function.
The equation proposed by Matthews et al.:
IRHOMA = I0 / (22.5 × e-In(Go) could be rewritten as:
IRHOMA = (I0 × G0)/ 22.5(mathematically:e-Inx =1 / x)
The QUICKI can be determined from fasting plasma glucose (mg/dl) and insulin (μIU/ml) concentrations.
QUICKI = 1/(logI0 + logG0)
The reported values of QUICKI were 0.382 ± 0.007 for non-obese, 0.331 ± 0.010 for obese and 0.304 ± 0.007 for diabetic individuals.
What happens if I dont have fasting blood samples?
Can I use HOMA still?
No, HOMA and QUICKI basically reflect hepatic insulin resistance while the measures after a glucose challenge rather reflect whole body insulin resistance (muscle, fat etc) or beta cell function. There are other indices for insulin/glucose dynamics such as insulinogenic index, matsuda etc
see
http://care.diabetesjournals.org/content/22/9/1462
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