Even in the BIOSPHERE experiments in Arizona (https://www.sciencedirect.com/science/article/pii/S0273117703001030) if i recall correctly, it was found that people were getting chocolate sneaked in! But you cant really ever control studies on diet. Biosphere was the closest you could come. But anywhere else, each person eats a bit differently and exercises a bit differently. Most dietary supplements are not stored equivalently and have different quality. What are you thinking of studying?