Combined anti-migraine therapeutics - gepant with magnesium. Is it meaningful?

09 December 2022 0 1K Report

Hello!

While full theory of migraine pathogenesis is not constructed, there are some types of anti-migraine agents.

Two among them are:

1) Gepants. Gepants are FDA approved drugs that acts as CGRP receptor antagonists.

2) Magnesium. Some trials were done to bind magnesium intracellular levels with migraine attacks. These data are not full but it was found correlation between magnesium deficience and migraine for some patients. And as preventive magnesium can reduce frequency of migraine attacks. Magnesium compounds are recommended by American Headache Society for preventive anti-migraine use.

How do you think, is multitarget magnesium-gepant complex (for example, magnesium-remagepant - remagepant functionalized for magnesium binding) viable option or not?

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