Yes Both human and experimental tumors, see the article.
The extracellular acidity and hypoxia that often accompany both human and experimental tumors The tumor microenvironment is characterized by regions of hypoxia and genes induced at low oxygen only at normal extracellular pH.hypoxia initiated in an acidification of the tumor tissue from pH 7.04 down to 6.65. (through resistance to hypoxia and acid-induced cell and Intracellular pH is maintained by multiple families of H+ transporters). I hope this information useful for your research
Yes Both human and experimental tumors, see the article.
The extracellular acidity and hypoxia that often accompany both human and experimental tumors The tumor microenvironment is characterized by regions of hypoxia and genes induced at low oxygen only at normal extracellular pH.hypoxia initiated in an acidification of the tumor tissue from pH 7.04 down to 6.65. (through resistance to hypoxia and acid-induced cell and Intracellular pH is maintained by multiple families of H+ transporters). I hope this information useful for your research
Aerobic glycolysis (Warburg effect) induces lactate accumulation, thereby reducing pH (=generating acidic conditions). It would be interesting to investigate into the resistance to acidic environment due to HIF1-alpha/ HIF-2 activation. How pH directly or indirectly affects the transcriptional factor distribution in the cell?
Article Metabolic reprogramming: The emerging concept and associated...
The paper below will give clear idea how Hypoxia modulate p53-glycolysis-MCT1-lactate axis (lactate export will regulate pH).
http://www.ncbi.nlm.nih.gov/pubmed/22184616
Yes hypoxia and extracellular acidity keep a strong relation. We described this relation in the unpublished paper that I am sending to you.
Yes, due to changes to a glycolitic metabolism, leading to increased uptake of glucose and production of lactate which is exported to the cell media. This will acidify the medium.
- Badges
- Science topic