I am wondering if there are any papers in which changes in gene transcription (e.g., from microarray or RNAseq experiments) or genome-wide epigenetic modifications (e.g., microarray-based DNA methylation experiments) were investigated after chronic stress in adolescence. This could be in any tissue, but preferably brain. I'm on the lookout, but perhaps I have missed some papers.
If anyone has a reference they would like to send my way that would be great.
Thanks in advance!
I assume you mean in rodents?
I don't know of any such papers, a lot of papers look at peripheral blood, and often at ages other than adolescents. I will try and look in more detail, but I don't know of a paper addressing your precise point.
Jon
Thank you, Jonathan. That would be great!
Yes, I am referring to rodents. I'm particularly interested in hippocampus, but PBMCs or some other cell type would be a good reference. Beggars can't be choosers. I agree with your statement about data in ages other than adolescence i.e., early-life stress in the neonatal period is common. I, of course, have had no problem finding papers in that regard.
On the other hand I have found one dataset in NCBI's GEO DataSets for the attached paper (Crews et al., 2012). The adolescent stress in this paper was more of a second-hand comparison group but this is a good example of the type of literature and datasets I'm looking for.
e-mail me [email protected] as we have some very preliminary (unpublished) maternal deprivation vs handling vs control whole genome methylation data from hippocampi that was taken during adolescence.
This data is currently confidential, but I will see what I can answer provately!
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