Hi everyone! I have had good luck asking questions before so I thought I should ask this. Has anyone else ever noticed that fat globules surrounding secretory tissue seem to prevent cells from emerging from the tissue? These are plated secretory tissue from bovine mammary glands. Fibroblasts and mammary epithelial cells emerge from tissue but I've noticed that there are none where there is a sort of "halo" of milk fat globules. Not sure if this is just a coincidence or maybe I just don't notice them as much when there are cells there.
I have the milk fat "halo" pictured and then a picture of emerging cells on another piece of tissue. Thank you.
Your observation made me to think a bit. As you know the fat globules are not just fat only, they are surrounded by a membrane called fat globule membrane which is equivalent to plasma membrane of mammary epithelial cell which secretes it.
There is possible that the milk fat globule membranes of milk fat globules (immediately touching the growing cells from your mammary tissue in culture) might be interfering their growth. You may verify by removing those fat globules and replace other media which has no fat globules or less fat globules in culture system if something change in cells derivation from mammary tissue. If this is true, think of applications of this finding
Nice innovative observation,
Good luck in your research
Subhash C. Juneja Thank you for your response. I did not mention, but I do think what you said is correct because I have also observed that sometimes cells will emerge from tissue and sort of stop at the milk globule "halo" sometimes they will somehow spread past the halo but do not seem to grow on top of it. I don't have pictures of this though. It is nice to see that you are encouraging some more observations on my part and I can be sure to gather evidence of this when I see it next. Thanks again!
Check https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/milk-fat-globules
Unfortunately, I do not have information in this field and I think that you can obtain information in your field of specialization by searching in scientific sites interested in this field. I wish you success and success.
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