Hi Angel,
I'm not aware of support for this idea yet. But we are working on it. In theory, the chemo/radiation kills off the bulk tumor cells, leaving the CSC behind. I believe that they will shift toward making more CSC progeny to try and regrow the tumor. We are using some in vivo tracking methods to try and answer this question.
Steve
Cisplatin is one answer
http://www.ncbi.nlm.nih.gov/pubmed/25200103
and how CSCs overcome cisplatin induced apoptosis
https://www.researchgate.net/publication/233742776_Blebbishields_the_Emergency_Program_for_Cancer_Stem_Cells_Sphere_Formation_and_Tumorigenesis_after_Apoptosis
Article Blebbishields, the Emergency Program for Cancer Stem Cells: ...
If you mean chemotherapy, I think the answer will be yes; chemotherapy causes asymmetric cell division, Cell resistant to chemo, genetic mutations,......
If you mean another treatments, please specify......
If you need any papers concerning about this issue, I can support you.
Dear Mahmoud,
Yes, in chemotherapy. I need to read papers about it.
In my simulations with an in silico model the conclusions were that constant low dose-intensity treatment is better than high-dose intensity treatment in order to difficult the asymmetric divisions of cancer stem cells.
Is there any evidence of that with in vitro or clinical studies?
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