(modified question after reading comments till 19/9/2013)
Thank you all for very informative comments.
I read alcohol is used to esterify free carboxylic acid (non-nutral) hope no such reaction happens on proteins. Does anybody have such information? One of the contributor (Hong Lok Lung) found 90% GFP loosing its function on alcohol treatment. Therefore, as suggested by many, I guess defenitely alcohol is effecting the teritiary structure of proteins. But how is it effecting teritiary structure of proteins, is it just because of change in external environment of proteins or is their any additional covalent modification causing to aminoacids in proteins.
Will RNAase (which take up teritiary structure on its own at nutral PH) loose its activity on treatment with alcohol? any information? any reference?