Dear Researchers,
One of My friend completed M.Sc., M.Phil., Computer science, He wants to do Ph.D in Computer science, he is skilled in scripting and other computer languages, hence, I suggested him to design a tool for bioinformatics need.
If you have any idea for suggesting a title or need for some essential softwares as free source. kindly suggest me.
It will be helpful for my two friends.
There are several software products that help users identify species, but I cannot find any that will help a user identify genera based on species characters as input, even if some genera would appear two or more times in different parts of the key. Genus identification is desirable because there are fewer items to handle in a project that covers a large area, for example a National project. This would be especially useful if the flora is very rich and imperfectly known. A project of this sort would also have a high profile because of its wide scope and broad base of potential users.
One of the "holy grails" in bioinformatics (or computational biology) is inference of biochemical networks from data, specifically inference (or reverse engineering) of dynamical models that not only predict time courses for unseen input data (starting conditions) but also reliable model network structure.
You may want to start at Marbach (2012): Wisdom of crowds for robust gene network inference, Nature Methods. I am also attaching a paper of ours, it has a number of good references. Maybe better to start there and then look at Marchbach.
Another area that is growing in recent times is multiscale modeling and simulation of biological systems.
One thing that is growing in Europe at the moment is systems medicine, and the modeling, analysis, simulation aspects. So here we adopt a systems view on human health and disease. You will find a number of good texts online.
Ultimately, data integration is the biggest challenge, I guess, and I doubt that there will be any general solution.
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