Bursting of DA neurons mobilized DA reserve pools in the terminals. This may produce dyskinesia. Could alpha2 antagonists target this via Ca?

02 February 2017 1 7K Report

We found that stimulation of the DA pathways in bursts reorganized DA storage pools. See: Role of alpha-synuclein in presynaptic dopamine recruitment.

Yavich L, et al. J Neurosci. 2004. How DA deficit affects this process is unknown, but it seems Ca depended. Alpha2 antagonists may target activation of storage pools. Please, let me know if you are interested.

Regards,

Leonid

Antonio Tito

I am interested in learning more about how I can help. I am using Drosophila as animal model to study dopamine related diseases and I am in the process of acquiring/making innovative genetic tools that could be useful to help you answer the question, in vivo. Looking forward to your response.

Best,

Dr. Tito

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