In experimental neuroscience, they use inactivated viruses to alter the genome of certain cells and make them produce fluorescent proteins to see them. I was wondering if such a mechanism was used to make vaccines? (to avoid a virus to integrate within the genome).
I think you're asking about editing viral genomes to inactivate them?
But you might be interested in the this paper showing edited B cells produce the desired antibodies which protect against RSV infection (the essence of a vaccine).
Article B cells engineered to express pathogen-specific antibodies p...
Andrew King thank you for your answer, no I am wondering if a vaccine works by editing the genome of the cell usually targeted by the virus (for instance in the case of flu, I am thinking of a vaccine that would edit the genome of the lung cells).
Romain Daniel Cazé ah I see. I haven't heard of such a thing being developed. I'd be interested if you could share a paper using the technique you're thinking of.
Andrew King, this is out of my field of expertise (I do research in computational neurosciences). Maybe some vaccine already works on this principle (I think of one not triggering the production of antibodies (but do it exist?)). A protocol would be to insert a gene coding for a fluorescent protein into the genome of the inactivated virus of an existing vaccine and then look at the cell usually targeted by the virus. This would not be a proof, but already a good hint.
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