In particular I'm interested if hypertension occurs in C57BL6 mice at any time after their 18th month of age. But I am also interested in other strains.
If you could point me to such studies I would highly appreciate that.
I have studied male C57BL6 up to the age of 15 months and I have not found them to show any sign of spontaneous hypertension. They have comparable blood pressures to juvenile animals (3 months) of about 120 mmHg systolic pressure. From extensive reading of the literature, I do not believe C57BL6 go on to become hypertensive with age unless there is some additional stressor (such as ATII infusion, as demonstrated by Zoltan Ungvari's recent publications).
I am not so familiar with other strains although I expect these also do not exhibit any profound hypertension with age. I think if you want to study this phenomenon, you might need a model of accelerated ageing (SAMPs, for instance), the use of SHRs or, as above, pharmacological/surgical intervention.
Ross.
I agree with Ross in that the C57BL6 mice are very resistant to having hypertension regardless of age. We had a very difficult time when we tried high fat diet-induced hypertension in these mice. We had them on a high fat diet 45% fat for 16 weeks and they barely became hypertensive. Unlike in sprague dawley rats where this diet induced significant hypertension at 9-10 weeks.
Hi,
Kindly see the followings:
http://www.genome.gov/10005834
http://www.sciencedirect.com/science/article/pii/0014299995000986
I'd also agree with Brandon re: HFD-induced hypertension. We reported a very modest increase in blood pressure following HFD in C57BL6 (Marshall et al. Hypertension. 2013 Jan;61(1):246-52) and really needed to severely stress the system with something like ATII in order to precipitate a clear degree of HTN (Smillie et al. Hypertension. 2014 May;63(5):1056-62).
However, if you have aged animals already, its possible that a HFD might be just enough of a stress to make them hypertensive?
Sirs,
thank you for your responses! It is in line with what I expected, that even the BL6 males are not likely to acquire hypertension easily. I will have to consider the challenges.
hi
i believe that mice (at least in NMRI mice that we have some experiences about it) is so resistance to HTN even in high ages, unless you apply any extra stress such as high fat diet or drug. moreover, if you apply stressors, it may be happen to mice that not be hypertensive!
good luck