Amended on 8 January 2019
I must sadly and repeatedly say that cancer is not caused by mutations and/or deletions at all (please see file; HepG2 fucoidan). Cancer specific marker proteins are not present in humans. Then, the idea of immuno therapy is absurd in humans.
My famous teacher Late Hon. Prof. Dr. Kunio Yamauchi (The University of Tokyo, Tokyo, Japan) has firstly shown that human breast milk or human mammary gland is deleted or is missing the genes of β-Lactoglobulin and α- S2 Casein. On the other hand, cattle has both genes. The absence of these genes in humans is not linked to cancer at all, but only linked to the species differences. Interestingly, we have recently found that the gene of milk or mammary gland biotinidase is present in humans but absent in cattle (please see file; The Fascio effect).
Cancer is caused by the co-infection of +ssRNA vira (Retrovirus, Flavivirus and/or Coronavirus). Recently, I have found that co-infection of HIV-1, HCV, and Hog cholera virus/CSFV or GB virus C/GBV-HGV/GBV-C is the cause of liver cancer patient to die. Therefore, dsDNA virus of Human papillomavirus/HPV and SV40/Simian vacuolating virus 40/Simian virus 40, and bacteria of Helicobacter pylori are not able to cause cancer at all.
I have found that HCC tissue (named as No.6; who has survived) has Breast cancer type 1 susceptibility protein/RING finger protein 53/RING-type E3 ubiquitin transferase BRCA1 at 7.4 μg/mg of tissue protein.
Hepatoma HepG2 has Breast cancer anti-estrogen resistance 2/Transcriptional-regulating factor 1 at 4.8, and Breast tumor novel factor 1/Chordin-like protein 2 at 0.97 μg/mg of tissue protein, respectively.
Healthy serum of 7mo1w boy has Breast cancer-associated antigen BRCAA1/ARID domain-containing protein 4B/AT-rich interactive domain-containing protein 4B at 4.1 μg/mg of serum protein.
Serum of 1y girl (with biotin deficiency and alopecia) has RING finger protein unkempt homolog/Zinc finger CCCH domain-containing protein 5 at 3.4 μg/mg of serum protein.
Therefore, BRCA1 is not linked to the cancer at all.
For HCC1937 this is correct. See:
https://web.expasy.org/cellosaurus/CVCL_0290
But this is not true for BT-483 and MDA-MB-231 which are BRCA1 wildtype. I double-checked in:
https://www.ncbi.nlm.nih.gov/pubmed/?term=16397213
and it confirms what I have: these 2 cell lines are wildtype BRCA1.
Best regards
Amos
Hi Ding
MDA MB 231 and BT483 cell line has WT BRCA1 while HCC1937 is BRCA1 mutant. Hope it helps!!
http://cancerres.aacrjournals.org/content/66/1/41.full-text.pdf
https://www.nature.com/articles/srep28217
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