Is there any anticancer agent which induces apoptosis rather than inducing the necrosis as they usually do?
Almost all anticancer agents induces apoptosis of tumor cell not necrosis. (massive apoptosis reviles as a tissue necrosis).
Here is a usfull link http://www.tocris.com/pharmacologicalBrowser.php?ItemId=187892#.Usg9_vu0OSo
you can find some chemicals (proapoptotic and other) and useful information
So, there is no short answer to this as there are a plethora of agents that should work. If you are looking for a positive control, then I would recommend agents that are routinely used and published with in the area you are studying with the cell line/lines you are using. Personally, I like the vitamin A derivative, fenretinide. MJ is not necessarily correct. The differentiation-apoptosis-necrosis axis is dependent on cell line, dose/concentration, and mechanism of action of the agent.
Thanks for the answering but can anyone please tell me their mode of mechanism.
Cancer therapeutics induced mitotic catastrophe in mitotically active cells which serves activate pathways associated with apoptosis in these cells.
For a mechanism of action see following reference: Cell Death Differ. 2006 Nov;13(11):1968-81
Generally speaking biologic therapies (like Gleevec) induced apoptosis rather than necrosis as they disrupt hyperactivated pathways and restore normal cell cycle in cancer cells. Classical chemotherapeutic agents usually induced cell death through necrosis.
Regarding the intimate mechanisms and mode of action you probably never receive answer here because of space limitations.
Different anticancer agents can trigger apoptosis, necrosis, autophagy, and also mitotic catastrophe, or senescence in leukemia cell populations.
you can check platinum-based drug like Cisplatin which cause cross-linking DNA and ultimately trigger apoptosis.
Apoptosis is triggered by various anticancer agents e.g. alkylating drugs, anthracyclines, also different potential anticancer agents
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