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Questions related from Arvind Negi
Hi all, I am looking for selective oxidation of cellulose by chemical treatment. Although, there are some methods reported, but are plagued with producing other oxidative forms of cellulose as...
24 August 2021 5,831 2 View
I have a protein-protein complex and therefore, need a visualiser to look at those amino acids which are at interface of these proteins. However I am also interested to see the interactions...
24 July 2015 2,142 14 View
when we do superpose of 3 pdbs together (1 on 2, 2 on 3, 3 on 1) and after that if we change the sequence of superposition, will there be any possibility to see the change in RMSD value (before...
18 June 2015 1,265 6 View
I have 6 receptors and only 1 ligand. In the meantime I interested to do the docking in all these receptor. Is there any way where we have a generalised way to dock this compound to these receptor...
28 November 2014 2,672 11 View
I want to know about the tools available for searching for a protein or receptor for a known ligand.
28 October 2014 576 8 View
What is the best reagent which can be useful in the reduction of 2,4-dinitrobenzaldeyde?
30 August 2014 6,473 15 View
Recently I was encountered with a problem where structure shown in figure is not able to get converted to any product. May be possibly due to its resonance effect or any other effect between the...
29 July 2014 10,031 17 View
Is there any anticancer agent which induces apoptosis rather than inducing the necrosis as they usually do?
04 January 2014 791 11 View
Cancer is heterogeneous diseases and it has extraordinary potential to survive even in adverse conditions (for e.g. hypoxia in the cancer cell). So its survival after these hurdles raises the...
23 December 2013 8,523 12 View
CH3F, CH3Cl, CH3Br, CH3I.
07 December 2013 1,283 6 View
Here I attached a snap shot of my data.
04 December 2013 5,733 12 View
Cancer shows lowered pH, what does this indicate and why cancer cell prefer to do this? Is anything relevant or edge that it can get after making the acidic micro-environment?
21 November 2013 8,968 19 View
Viruses are nucleoproteins and they are useful in drug delivery but can they be helpful in transmitting the area of interest gene to the receiver?
19 November 2013 7,698 1 View
Topology prediction is a bioinformatics tool which assist in mapping the surface of the functional protein. But normally this functional protein is membrane protein. Why we can't do the topology...
12 November 2013 9,056 3 View
Normally we use AMBER and CHARMM for protein minimization. Can anyone tell me which one is better AMBER or CHARMM?
10 November 2013 6,217 3 View
Insulin, like growth factor receptor-1 (IGF-1R) is well characterized in cancer and there are lots of clinical agents in preclinical development phase, but still there is no drug or no clinical...
07 November 2013 3,959 2 View
Recently histamine-3 receptor was discovered but its physiological role is unknown. Is there any report related to this concern?
07 November 2013 1,975 3 View
Splicing an insulin gene results in two isoforms of the insulin receptor, A and B, where A implicates a mitogenic effect and B a metabolic effect. But for the mitogenic effect, IGF-1R is present...
07 November 2013 6,468 1 View
Parasite need host for its survival and to regulate its life cycle. Since last some decade we are fortunate to find out the novel target in their metabolism which are absent in human. And mainly...
01 November 2013 3,769 1 View
Normally TLC spotting is done to evaluate the reaction completion. But often I get tailing in TLC. I don't know why?
01 November 2013 1,186 17 View
Usually we can prepare homology model, but problem comes in their evlaution. What are various ways to evaluate the homology model?
23 October 2013 677 6 View
Online software to make the phylogentic tree on the basis of the amino acid sequence of novel protein.
23 October 2013 7,948 2 View
What are the different ways to evaluate a loop in a homology modelor loop modelling?
23 October 2013 1,123 1 View
Insulin has metabolic and mitogenic effect too. Thereby can be helpful in proliferation of neurons which are degenerated in certain brain diseases like Alzeihmer and Parkinson's.
19 October 2013 1,576 9 View
Insulin Receptor and IGF-1R are structural homologous to each other therefore their ligands share common signalling but the selectivity is only possible when we they better understanding of their...
19 October 2013 8,015 0 View
Normally patient are dripped with 0.9% NaCl. Is there any other salt or its conc. Which replace the traditional way.
18 October 2013 5,116 6 View
Insulin is the first polypeptide hormone discovered. But it still doesn't have an antagonist?
09 October 2013 5,330 3 View
I often encountered both these term, when I was reading a chapter in biochemistry.
29 September 2013 5,508 11 View
Storing of DNA is required for long time use
29 September 2013 5,747 9 View
In terms of new findings and new discoveries.
29 September 2013 9,823 1 View
Is lactic acid a pain mediator?
28 September 2013 7,055 2 View
There are so many softwares for docking but which one is best? On which we have to rely?
28 September 2013 7,996 1 View
APE repairing enzyme, a druggable target.
28 September 2013 1,527 1 View
Repairing enzyme APE has two terminals: C-terminal and N-terminal. Now the role of APE repair enzyme is well characterized but its both terminal participate in cancer progression. So which one is...
28 September 2013 7,692 1 View
Is there any particular protocol to follow for this kind of assay?
27 September 2013 241 2 View
The spleen is highly affected by systemic infections and consequently suffers from several disorders and problems. But are there any biomarkers or tests through which we estimate the functionality...
27 September 2013 3,888 1 View
Tyrosine kinase (TK) are essential components in humans and their role has been manifested in many diseases. Normally we used to synthesise the TK inhibitors. So I want to know is there any plant...
25 September 2013 5,036 7 View
Human body consist of around 90 tyrosine kinases. If one tries to target them selectively then what are the factors or measure he/she must be carefully employed? For instance, if a inhibitor is...
25 September 2013 4,669 6 View
Drugs either bind to the substrate or cofactor binding site but which one is better to target?
25 September 2013 7,713 5 View
Why does the spleen become enlarged during malaria?
18 September 2013 4,623 19 View
