The conclusions are drawn from only 14 cancers in the treatment arm, so it will be interesting to see if any other studies confirm this. There are a few issues that stick out in my mind, the first is that quantity and regularity of sildenafil use was not able to be determined, which I think is a critical piece of information to confirm exposure and determine the level of exposure. Secondly, I could not quite determine whether this was addressed, but I would be interested to know if their were differences in skin cancer screening between the two groups. Sildenafil use, and the associated doctors appointments may bring patients into contact with the medical community more often, increasing the screening in the treatment group.

As far as I know, there is no knowlegde about this issue yet. I don´t think that the Inhibition of PDE V is involved in the pathogenesis of melanomas. We just use PDE V-Inhibitors a long time on a huge number of patients. In my opinion these results should be confirmed in a greater number of patients.

I keep wandering how the Inhibition of PDE V could be a trigger for melanoma or could increase its risk. I think there is a lack of information in this paper that can lead us to mistaken aguments.

The prescription of sildenafil needs regular medical visits. Also there are more examinations of the body, that means a higher chance of discovery of visible tumors like melanoma - I believe the cited study showed a bias.

Thanks Klotz

I do agree with you.

I`m waiting for more coments on this subject to summarize it.

Use of viagra does not cause the development of melanoma.

Article Meta-Analysis of the Association Between Phosphodiesterase I...