Rodent Models

Dear colleagues, please tell us how to do intranasal administration to mice (method)?How to minimize animal stress?

We have never done this procedure, so will be grateful for all  details. What  equipment is required? What are the minimum and maximum treatment volume? How better to hold a mouse for this...

08 August 2014 1,230 9 View

Does anyone know about endothelin 1 induced stroke in rodents?

It seems that endothelin 1 would induce some more cellular changes, like those in neurons and astrocytes. What else we can use instead of endothelin 1?

06 June 2014 6,680 2 View

Have you changed how experiments are run in your behavioral lab, to avoid experimenter gender issues?

Based on Sorge et al. 2014: Experimenter sex can alter behavioral baseline responses (Nature...

22 May 2014 8,888 6 View

What systems are recommended for rodents ERGs?

We are looking to purchase an ERG system to test rodent RGCs, can anyone offer any advice as to which systems/companies are better than others? If possible we'd like to buy a system that combines...

05 May 2014 10,140 3 View

What behavioral tests in rodent models of orofacial inflammatory pain are considered the best ones to verify the action of pharmacological agents?

Based in your experience in research, what tests are more applied to evaluation of nociception behavior in orofacial region (skin, muscles or sinovial joint)? Thank you for your answer.

22 April 2014 7,993 3 View

What is the best procedure for culturing a mouse E18, cortex and hippocampus neuron?

What are the main factors that affect proliferation and differentiation E18 rodent neuron culture.

04 April 2014 5,611 0 View

What behavioral tests in rodent models of orofacial inflammatory pain are considered the best ones to verify the action of pharmacological agents?

Based in your experience in research, what tests are more applied to evaluation of nociception behavior in orofacial region (skin, muscles or sinovial joint)? Thank you for your answer.

04 April 2014 1,149 4 View

Can anyone tell me the difference between a normal colon and colon cancer in rodents?

There is a difference between normal and cancerous tissue of the colon of rodents after injection with 1,2- DMH for 15 weeks.

21 March 2014 5,229 1 View

Can anyone tell me the difference between a normal colon and colon cancer in rodents?

There is a difference between normal and cancerous tissue of the colon of rodents after injection with 1,2- DMH for 15 weeks.

03 March 2014 1,536 1 View

How many subjects (rats) does one require to establish statistical significance of an experimental effect in a resting state fMRI study?

It's a pharmacological intervention wherein we are trying to test an a priori hypothesis about decreased functional connectivity in a subset of networks involving the hippocampus in a 9.4T scanner.

02 February 2014 5,497 4 View

Any suggestions for target journals that might be interested in this research?

As a proof-of-concept, we utilized a novel, low-touch, digital platform for phenotyping rodent models of disease for preclinical research to create the Vium Arthritis Index™ (VAI), an objective...

01 January 1970 8,240 0 View

Is gender-oriented biological or medical research equal to a biased study?

Most of biological and medical investigations choose to involve either male or female (rarely both) subjects to study. To merely include subjects from one gender (particularly males in rodent...

01 January 1970 6,163 9 View

Are there any results on the metabolic mass (BMR) of young mice between birth and P20?

Hello, I am looking for a publication that would allow me to estimate the metabolic mass of young mice, from their birth to adulthood. Do you know of any publications?

01 January 1970 1,381 3 View

Is gender-oriented biological or medical research equal to a biased study?

Most of biological and medical investigations choose to involve either male or female (rarely both) subjects to study. To merely include subjects from one gender (particularly males in rodent...

01 January 1970 1,076 8 View

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01 January 1970 569 0 View

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01 January 1970 9,389 0 View

Is there any rodent model for sleep deprivation (restricted sleep) that requires wet cage/bedding? | ResearchGate

There are other methods of sleep deprivation that includes some of the automated setups validated and published couple of years back. But I am looking for the wet cage method of restricting sleep....

01 January 1970 9,348 0 View