It seems that endothelin 1 would induce some more cellular changes, like those in neurons and astrocytes. What else we can use instead of endothelin 1?
what rodents are you thinking of.
it works very well in mice and rats with the one advantage that you will get re-perfussion once the vasoconstriction relaxes about 24 hrs later.
another model that works well in mice and so so in rats is photothrombosis. light sensitive dye is injected followed by laser over the region of brain you want to stroke. no reperfusion happens with this.
we use both these models but there are others to think of as well
there is a review in BJP from 2011 that you should take a look at.
Preclinical stroke research- advantages and disadvantages of the most common rodent models of focal ischemia
hope this helps
anthony
Thank you very much. Just we are thinking of that endothelin 1 may induce a lot of unwanted effect in rats. Thus, I would like to have some advice from you guys.
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