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Questions related to Bioinformatics
Hi, I'm working on sequence alignment algorithms. My background is Computer Science. Given two sequences, what could be the max length of a gap and how many insertions/deletion at one stretch I...
11 November 2019 2,337 10 View
Hi everyone, I am an undergrad student in bio informatics doing some research on a protein called OPA3 with an unknown function. I am having a hard time interpreting the phylogenetic tree. I need...
11 November 2019 5,884 3 View
Hi everybody I want to study the inference of the admixed population into different ancestries but I can't understand why it's important to consider the background linkage disequilibrium (LD)...
11 November 2019 1,305 4 View
Is there any tool or program to predict the synergy of two drugs based on bioinformatics without experimental data. I've more than 30 active TCM compounds that target hypertension associated...
11 November 2019 6,354 3 View
I'm trying to annotate a yeast's genome using FunGAP but it stopped in the run4 of Maker. The gmes log said that I may need to install YAML module, as follows: Can't locate YAML.pm in @INC (you...
11 November 2019 3,508 2 View
I am still new in bioinformatics field and now I am having an internship in MGI. Recently, we are given 2 sets of exome data which are diabetes type1 and diabetes type2. We already did with...
11 November 2019 2,401 2 View
My goal is to align my metagenomic sequences with virulence gene database in order to find out which probable genes are prevalent in the data. So I ran diamond aligner using following...
11 November 2019 2,546 2 View
Would you please tell me what come in the genomics and bioinformatics skills? What is difference between Bioinformatics and Transcriptomics?
11 November 2019 2,636 3 View
Do you know any database for searching about endemic species, their genomes, differences, DNA barcodes etc.?
11 November 2019 1,411 3 View
As nude mice still has Bcells,NK cells and DC cells. Will K562 cell lines survive in Balbc nude mice to create a xenograft model. There are very few publication who used this strategy to test...
07 November 2019 1,022 1 View
I did Pearson correlation analysis between two variables for group A and group B. then, In order to investigate whether a significant difference between the correlations for group A and the...
23 October 2019 7,038 6 View
Hi everyone. I am newbie Phylobayes user :) I recently started running phylobayes-mpi on Cipres portal for Multilocus phylogeny with 5000+bp. Although I run my analyses with parameter...
20 October 2019 8,461 10 View
If we conside silver silver nanoparticles have more antimicrobial property of silver oxide nanoparticles has. Metal oxide nanoparticles show antimicrobial property.Why lot of research is taking...
16 October 2019 4,719 5 View
I am trying to identify enriched regions(peaks) between m6A RNA methylation RIP-seq and input data. For that, the human genome need to be split into non-overlapping 20 nt windows, then I need to...
12 October 2019 930 6 View
10 October 2019 3,885 6 View
I have bam files (3 IP and 3 input) from a RIP-seq experiment. I need to split each unique mapped reads bam file based on read strand in order to calculate then strand-specific read coverage along...
10 October 2019 7,830 3 View
I am new to the field of molecular phylogeny. I am interested in knowing the bioinformatics applicable in molecular evolution.
10 October 2019 473 3 View
Hi all, We recently started working on the COLO320 xenograft model and are trying to figure out the best time point to terminate the study for quantification of lung and liver mets? We currently...
17 September 2019 9,134 0 View
Hi, I have a list of some genes and i want to check their interaction with my target. Anyone can suggest some bioinformatic tools that can predict the interaction?. many thanks
09 September 2019 8,931 9 View
I have a very specific problem while modeling PZ (Protein Z). The protein is a molecule of 360 residues with a Gla domain (1-46), two EGFs (47-126) and an SP like domain (135-360). When looked for...
09 September 2019 9,218 7 View
Especially in public health
09 September 2019 6,178 4 View
I've got microarray transcriptomic data (from S. cerevisiae) - and I've made GO enrichment analyses - since there were many redundant GO terms I've used REVIGO for getting rid of them but I found...
09 September 2019 829 6 View
Protein on which i am working is a disordered protein and no crystal structure of this is available on PDB. I have modelled structure using I-TASSER. Out of top five models generated by I-TASSER I...
08 August 2019 5,584 9 View
I have tried to construct it using Chemsketch but unable to convert it to pdb format. I want to use glucose-2-phosphate in docking study and hence in need of 3D structure.
08 August 2019 4,316 7 View