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Questions related from Arvind Negi
Hi all, I am looking for selective oxidation of cellulose by chemical treatment. Although, there are some methods reported, but are plagued with producing other oxidative forms of cellulose as...
24 August 2021 5,889 2 View
I am unable to run Autogrid command by cygwin. Is there anybody know the right commands to work in cygwin.
11 March 2016 6,628 10 View
I did a simple organic reaction where I left with excess of Polyhydroxymethylsiloxane (PHMS) in the final product solution. I tried to extract it with aqueous layer, but I failed. Let me know, if...
14 September 2015 1,861 3 View
I have a protein-protein complex and therefore, need a visualiser to look at those amino acids which are at interface of these proteins. However I am also interested to see the interactions...
24 July 2015 2,218 14 View
when we do superpose of 3 pdbs together (1 on 2, 2 on 3, 3 on 1) and after that if we change the sequence of superposition, will there be any possibility to see the change in RMSD value (before...
18 June 2015 1,336 6 View
I have to do docking for peptides and small molecules. So, to maintain uniformity in methodology, I need a suitable forcefield which equally good for peptides as well as small molecules.
24 March 2015 9,103 28 View
I have 6 receptors and only 1 ligand. In the meantime I interested to do the docking in all these receptor. Is there any way where we have a generalised way to dock this compound to these receptor...
28 November 2014 2,737 11 View
I want to dock a carbohydrate molecule as a ligand on a protein. What is the best scoring function/force field that I can use for this type of docking?
04 November 2014 2,171 5 View
I want to know about the tools available for searching for a protein or receptor for a known ligand.
28 October 2014 637 8 View
I reduced the Dinitro containing compound in the Iron H2SO4 and now I want to isolate the product.
11 September 2014 3,321 14 View
What is the best reagent which can be useful in the reduction of 2,4-dinitrobenzaldeyde?
30 August 2014 6,537 15 View
I was using haddock protein protein interaction software in centos 6.5 (phython 2.6) where I got this Message. OSError: [Errno 2] No such file or directory:...
30 July 2014 3,919 1 View
Recently I was encountered with a problem where structure shown in figure is not able to get converted to any product. May be possibly due to its resonance effect or any other effect between the...
29 July 2014 10,096 17 View
Please tell me how I can evaluate my method: Suppose there are various sub-units namely: A,B, C, D, E. These can integrate to each and can form a complex at particular energy. Can I estimate...
10 January 2014 3,817 4 View
Is there any anticancer agent which induces apoptosis rather than inducing the necrosis as they usually do?
04 January 2014 856 11 View
Cancer is heterogeneous diseases and it has extraordinary potential to survive even in adverse conditions (for e.g. hypoxia in the cancer cell). So its survival after these hurdles raises the...
23 December 2013 8,612 12 View
CH3F, CH3Cl, CH3Br, CH3I.
07 December 2013 1,344 6 View
We often use these irrespective of their meaning.
07 December 2013 5,923 4 View
Here I attached a snap shot of my data.
04 December 2013 5,801 12 View
Cancer shows lowered pH, what does this indicate and why cancer cell prefer to do this? Is anything relevant or edge that it can get after making the acidic micro-environment?
21 November 2013 9,031 19 View
Viruses are nucleoproteins and they are useful in drug delivery but can they be helpful in transmitting the area of interest gene to the receiver?
19 November 2013 7,757 1 View
Topology prediction is a bioinformatics tool which assist in mapping the surface of the functional protein. But normally this functional protein is membrane protein. Why we can't do the topology...
12 November 2013 9,110 3 View
Normally we use AMBER and CHARMM for protein minimization. Can anyone tell me which one is better AMBER or CHARMM?
10 November 2013 6,280 3 View
Recently the role of telomerase was identified in cancer.
10 November 2013 7,528 4 View
We know the insulin more as metabolic hormone but recently i read a news published in nature supplement about its role in immunity. can i get more information in this concern.
09 November 2013 4,554 8 View
I am writing a paper and I need a software whose evaluation can be published?
08 November 2013 6,683 7 View
Insulin, like growth factor receptor-1 (IGF-1R) is well characterized in cancer and there are lots of clinical agents in preclinical development phase, but still there is no drug or no clinical...
07 November 2013 4,017 2 View
Recently histamine-3 receptor was discovered but its physiological role is unknown. Is there any report related to this concern?
07 November 2013 2,033 3 View
Splicing an insulin gene results in two isoforms of the insulin receptor, A and B, where A implicates a mitogenic effect and B a metabolic effect. But for the mitogenic effect, IGF-1R is present...
07 November 2013 6,535 1 View
hERG is related to cardiac rhythm and is evaluated mainly in relation to kinase inhibition. Why is this?
07 November 2013 9,844 2 View
Is there any alternative way to prevent this loss.
07 November 2013 6,071 83 View
Usually -OH group (-OH group of serine, threonine and tyrosine) gets phosphorylate. Why can't other groups phosphorylate like -SH (thiol of amino acid)?
06 November 2013 6,306 3 View
Madness is the mental disorder where a person is unable to understand the present circumstances. But how does it happen?
05 November 2013 2,499 5 View
Imine bonding is what we get in stilbene structures and imidazole are simply hetrocycles. Is there any report related to the pharmacophore or any structure which cover both the things?
05 November 2013 2,587 0 View
Normally Hb carries 4 oxygen atoms, but is there any condition where it carries more than 4?
03 November 2013 4,929 0 View
Parasite need host for its survival and to regulate its life cycle. Since last some decade we are fortunate to find out the novel target in their metabolism which are absent in human. And mainly...
01 November 2013 3,834 1 View
Normally TLC spotting is done to evaluate the reaction completion. But often I get tailing in TLC. I don't know why?
01 November 2013 1,254 17 View
I need to see hybrid receptor formation and their interaction.
01 November 2013 7,501 0 View
Now-a-days, I often heard about the COX-2 inhibitors are being used in cancer. But as my best of knowledge I know that they are useful in inflammatory conditions.
29 October 2013 2,655 6 View
I read in Mangan et al 2004, that helminth infection protect from the anaphylaxis shock. That indicate that the other worm infection can also be beneficial in case of anaphylaxis shock. Is it so?
29 October 2013 8,281 1 View
There are two docking algorithms: genetic and lamarckian. What is the difference between them and how do results differentiate between them?
26 October 2013 6,387 11 View
Usually we can prepare homology model, but problem comes in their evlaution. What are various ways to evaluate the homology model?
23 October 2013 748 6 View
Online software to make the phylogentic tree on the basis of the amino acid sequence of novel protein.
23 October 2013 8,007 2 View
What are the different ways to evaluate a loop in a homology modelor loop modelling?
23 October 2013 1,185 1 View
Normally it was observed that plant grow in cold climate had produced bigger amount of resveratrol. Whereas further research finding indicate a surprising conclusion that it is because, in cold...
22 October 2013 2,379 5 View
Insulin has metabolic and mitogenic effect too. Thereby can be helpful in proliferation of neurons which are degenerated in certain brain diseases like Alzeihmer and Parkinson's.
19 October 2013 1,643 9 View
Insulin Receptor and IGF-1R are structural homologous to each other therefore their ligands share common signalling but the selectivity is only possible when we they better understanding of their...
19 October 2013 8,067 0 View
Normally patient are dripped with 0.9% NaCl. Is there any other salt or its conc. Which replace the traditional way.
18 October 2013 5,187 6 View
Can any one tell me the possible explanation of Anaphase bridge formation in onion root meristem during genotoxicity evaluation?
10 October 2013 3,295 1 View
Insulin is the first polypeptide hormone discovered. But it still doesn't have an antagonist?
09 October 2013 5,402 3 View
I often encountered both these term, when I was reading a chapter in biochemistry.
29 September 2013 5,570 11 View
Storing of DNA is required for long time use
29 September 2013 5,808 9 View
In terms of new findings and new discoveries.
29 September 2013 9,891 1 View
I read so many reports where it is mentioned that sometimes it happen that plasmodium is left in the liver without being affected by the drug regimen and then suddenly it reappears.
29 September 2013 8,354 6 View
Is lactic acid a pain mediator?
28 September 2013 7,233 2 View
There are so many softwares for docking but which one is best? On which we have to rely?
28 September 2013 8,064 1 View
APE repairing enzyme, a druggable target.
28 September 2013 1,589 1 View
Repairing enzyme APE has two terminals: C-terminal and N-terminal. Now the role of APE repair enzyme is well characterized but its both terminal participate in cancer progression. So which one is...
28 September 2013 7,745 1 View
C-terminal of APE enzyme involve in repairing of DNA while N-terminal in redox activation of transcription factors. Is there any report when both terminals work together in signalling or come...
28 September 2013 5,164 4 View
Normally it is chronic and only diagnosed after when patient suffer from severity symptoms. Therefore I want to know is there any method of its early detection.
28 September 2013 2,203 16 View
Is there any particular protocol to follow for this kind of assay?
27 September 2013 300 2 View
The spleen is highly affected by systemic infections and consequently suffers from several disorders and problems. But are there any biomarkers or tests through which we estimate the functionality...
27 September 2013 3,941 1 View
Inhibiting of Tyrosine kinase (TK) of EGFR is a method of treating cancer but the compound has to target the TK of EGFR.
27 September 2013 3,300 0 View
Normally these amino acids are differentiated only by para-hydroxy which is present in Tyrosine and absent in Phenylalanine.
27 September 2013 8,602 1 View
Tyrosine kinase (TK) are essential components in humans and their role has been manifested in many diseases. Normally we used to synthesise the TK inhibitors. So I want to know is there any plant...
25 September 2013 5,095 7 View
Human body consist of around 90 tyrosine kinases. If one tries to target them selectively then what are the factors or measure he/she must be carefully employed? For instance, if a inhibitor is...
25 September 2013 4,719 6 View
Drugs either bind to the substrate or cofactor binding site but which one is better to target?
25 September 2013 7,779 5 View
Tyrosine kinases possess a ATP binding site which was exploit to design kinase inhibitors for different human disorders.
25 September 2013 2,643 0 View
These amino acids play a vital role in maintaining normal physiology of the body and only selected amino acids are to show these interactions. It means the study of these interaction is quite limited.
25 September 2013 466 0 View
Why does the spleen become enlarged during malaria?
18 September 2013 4,681 19 View
Megapixel of human eye
18 September 2013 3,064 2 View
Reactant is 5-amino-4-cyano-imidazole ring, tried so many methods but yet can't get any success. I tried around 37 methods to get tetrazole but if u will draw the structure you will find the...
17 September 2013 3,345 7 View
