Here are some tricks Plasmodium applies

in order to hide from immune system.

http://www.sciencedaily.com/releases/2006/08/060805131802.htm

http://www.sciencemag.org/content/313/5791/1287.abstract

http://www.eurekalert.org/pub_releases/2006-01/hhmi-mpd011906.php

http://scienceblog.com/7486/researchers-unmask-malaria-parasites-cloaking-mechanism/

pfEMP1 makes infected red blood cells sticky so

that they are glued onto the blood vessels.

http://www.eurekalert.org/pub_releases/2009-11/wt-srm113009.php

http://www.eurekalert.org/pub_releases/2012-01/waeh-um011712.php

http://phys.org/news/2012-01-unveiling-malaria-invisibility-cloak.html

A possible therapy might be making parasited

more visible to the immune system.

http://www.eurekalert.org/pub_releases/2011-12/uoih-run121211.php

http://medicalxpress.com/news/2011-12-bloodstream-malaria-infection-mice.html

Regards,

Joachim (not a medic)

Yes, it is.

Some Plasmodium species form hypnozoites, which are dormant forms of the parasite in the liver, that can be reactivated months or even years (decades!) after the first episode of the disease. This is the case of Plasmodium vivax and Plasmodium ovale.

Yes. Usually Primaquine is prescribed to target hypnozoites. However, it is not a fool proof drug.

The hypnozoites are responsible for relapse . The morbidity is high with P.V in India. Therefore, relapse is a concern. Primaquine targets hypnozoites, as rightly pointed by Sumodan PK, how effective it is a question. lalitha kabilan

Chronic malaria results due to prolong liver involvement and splenic index is used as a predictor