I am preparing some high quality genomic DNA for NGS and some of my sample have high RNA concentrations. I would like to treat them with RNAse, but I've had some previous problems of DNA degradation due to RNAse. So I am trying to figure what will be the best option: leave it with the RNA or add RNAse. Additionally, I've purchased a RNAse that will not be inactivated by heating (only spin column and phenol/chlorophorm), so I was wondering if the left over RNAse will affect my DNA quantification using the pico-green method.