What are the current limitations regarding the antimicrobial susceptibility methods, standard procedures implementation, and workplace communication between the clinicians and the microbiology laboratory staff that hinder the fight against antibiotic resistance development?
you should not be asking your schoolwork questions on this forum
Antibiotic resistance the global problem for 21 century and for future. All come from stupidity of so called doctors who without any antibiotic resistance testing usually recomending drugs.
Is this for a school assignment? Seems like several of your classmates also posted questions in this forum.
Anyway, I can think of two possible answers to your question:
1. Standard antimicrobial susceptibility tests do not reflect the resistance patterns of biofilm bacteria. Since the design of routine lab tests facilitate the growth of only the planktonic phenotype, the isolate may appear susceptible even if the organisms that formed biofilms inside the patient (biofilm phenotype but of the same species and strain) are resistant to the antibiotic. Biofilm phenotypes are generally more resistant to antibiotics compared to their planktonic counterparts. This then leads to the failure of antibiotic therapy even if the isolate appeared susceptible to the antibiotic during lab testing. This is of course only a problem in cases of biofilm-associated infections.
2. Standard antimicrobial susceptibility reports do not usually include the MICs because most physicians prefer the S,I, or R reports. While this may not be an issue at the level of individual patient management, information is lost that may be useful for surveillance of antimicrobial resistance at the community level. If the MICs are routinely recorded and made available for surveillance, we may potentially “catch” the development of biological resistance before clinical resistance is achieved. In other words, if the records show a trend of increasing MICs over time for a given species and antibiotic (even if still within the range of clinical susceptibility), this may serve as a clue that a clinically resistant strain may appear in the future.
please look at the publications of F. Schaumburg, University Münster, Germany
- Badges
- Science method
- Similar topics
- Biological Science
- Ecology