Until recently little attention has been paid to the possible role bacteria may play an induced neoplasia.
If neoplasia can be induced by microbe ( H. Pylori Adenocarcinoma and MALT lymphoma) it is reasonable to suggest that some cancers might be cured by antimicrobial agents.
It is widely assumed carcinogensis is a reverse or convergent evolutionary process. Such evolution reflects absence of taxonomic barrier and so it is wisely to think some cancer cells have primitive features.Thus, they respond to some antimicrobial agents e.g. Metronidazole, Artemether. In addition, Doxycycline and Macrolides (Clarithromycin) as well. Interestingly, BCG vaccine - normally used for immunization against TB- had been shown having promising results against prostate cancers. In this regard, I attach our old paper that discusses the possible interrelation between cancer and lower micro-organisms.
Dear John thanks as much as I know Blastocystis hominis may be an antigenic to humans to cause Chronic idiopathic Uriticaria (CIU) but not record to cause any skin neoplasia. Dear Abadi greetings and thanks for links I will revise and feed you back
Hi Ali Abdil Razzaq,
The term of antibiotics are biological products originated from biological microorganisms to inhibit growth of other microorganisms. Penicllin and its derivatives are antibiotics because they originated from fungi Penicillium notatum. Tetracycline is an antibiotic because it was originated from Streptomyces sp, etc...
Although Daunomycin is an antibiotic, originated from Streptomyces sp., but never used as antibacterial or generally anti-infectious agents.
Khalid
Some cancers might be cured by antimicrobial agents.
Anthracyclines are anticancer compounds that were originally derived from Streptomyces and their anti-tumor activities were established in the 1960s .
1.Danorubicin is used in treating acute lymphoblastic and myeloblastic leukaemias.
2.Doxorubicin is one of the most widely used chemotherapeutic agents and is generally prescribed in combination with other drugs. Doxorubicin has a broad spectrum of activity. It is one of the most effective drugs for solid tumor treatment, e.g., breast cancer, small cell lung cancer and ovarian carcinoma treatments. It is also active against multiple myeloma, several types of leukaemia and cutaeneous T-cell lymphoma.
Due to development of resistance in the tumor cells to daunorubicin and doxorubicin, dose dependent cardiotoxicity, and several other side-effects, modification of these drugs to produce analogs with wider activity and lower toxicity have been sought. However, only very few anthracycline analogs like epirubicin and idarubicin have been approved for clinical use.
Dear Dr Khalid/ Dr Gama thanks for valuable knowledge about antibiotics used for treatment in malignancy per se, can we use antibiotics against the microbe itself to stop neoplastic process itself e.g MALT lymphoma and H. pylori
Yes, some Antibiotic used for treatment in Malignancy, like,
Bleomycin
Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
Mitomycin
Mitoxantrone
- Badges
- Science topic
- Similar topics
- Chemistry
- Pharmacology
- Medical Pharmacology
- Clinical Pharmacology