Why won't (p53 deficient) cancer cell growth rate increase when infected with ONYX-015?

12 April 2015 1 2K Report

ONYX-015 can replicate in cancer cells via interaction between E2F and E2 promoter (in cells with non functional p53 pathway). But cancer cells also have these E2 receptors so they should divide with the virus (so this oncolytic virus should not be able to lyse the cell because with increase in virus numbers call number also increases).

Divaker Choubey

It has been proposed that E2F-dependent replication of virus in p53-deficient cancer cells leads to virus -induced cell lysis. Consequently, cancer cells are unable to proliferate.

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