Probably due to the lack of substrate specificity. Lysosomes remain intact as long as the active sites of their membrane are not exposed to the enzymes.

Dear Gustav van Niekerk,

Please read the following text which was taken from different sources:

Inside the lysosome membrane there is a thick "glycocalix" protective layer. This "glycocalix" is made of special proteins called "Lysosome associated membrane proteins (LAMP)" and sugars "polylactosamine."

Source: The lysosomal leaflet of the limiting membrane is covered with a thick glycocalix that protects the membrane from attack by the membrane-degrading enzymes present in the lysosol. This glycocalix is formed by lysosomal integral and peripheral membrane proteins, which are highly N-glycosylated with polylactosamine units and therefore highly resistant toward lysosomal digestion (Eskelinen et al. 2003).

Eskelinen E-L, Tanaka Y, Saftig P. 2003. At the acidic edge: emerging functions for lysosomal membrane proteins. Trends Cell Biol. 13:137–145

Kolter T, Sandhoff K. 2005. Principles of Lysosomal Membrane Digestion: Stimulation of Sphingolipid Degradation by Sphingolipid Activator Proteins and Anionic Lysosomal Lipids Annu. Rev. Cell Dev. Biol. 21:81-103.

Lysosomes have a limiting membrane, which is composed of a single-lipid bilayer and integral and peripheral proteins, and an acidic lumen that contains soluble hydrolytic enzymes and activators47, 48, 49, 194, 195. A glycocalyx lines the internal lysosomal perimeter, protecting the membrane from the acidic environment of the lumen. Soluble enzymes are directly involved in the degradation of metabolites, whereas the lysosomal membrane segregates this catalytic potential and also actively participates in the maintenance of plasma membrane integrity, the establishment of the acidic pH of the lysosomal lumen, metabolite and ion transport, lysosomal trafficking and catalysis.

http://www.nature.com/nrm/journal/v14/n5/box/nrm3565_BX1.html

Hoping this will be helpful,

Rafik

Dear Prof Karaman

Thank you kindly for the detailed response and accompanying reverence to relevant literature. It is greatly appreciated!

See the answer by Rafik;

If you disturb the energy charge of the cell, the low ATP cannot maintain the integrity of the lysosomal membrane and it breaks; See article by Gilloteaux et al about RT4 in Ultratsructural Pathology of 2010 where I have submitted an image of that;

In addition, please read aricles from de Duve group who discovered the lysosome and peroxisome for his Nobel in 1974;

Probably there are three possibilities

First / the presence of sugar groups lining the membrane from the inside and preventing its decomposition.

Second / spacificity, as enzymes have their own substances that they work on, and the composition of the membrane does not fit those enzymes.

Third/ I think that the three-dimensional structure of membrane proteins is formed so that the weak bonds are hidden inside the membrane, which prevents its decomposition.