Why does combination therapy seem to be more effective for kidney cancer? Wouldn't you have more side effects due to consuming two drugs at the same time?
Because it targets key pathways by synergistic or an additive manner
Because it block the oncogenesis in different ways. Prohibiting the uncontrolled growth by multiple mechanisms.
Combination therapy may be more effective than single therapy in significant number of studies or situations, but the reason may be difficult to explain. It may be because the different chemicals may be attacking the tumor cells at different targets thereby increasing their efficacies(synergistic effect). Newer combination therapy have targeted at using the bodies own immune system to attack the tumor cells thereby reducing the growth of the tumors.
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