Muscle growth and differentiation. How does the myotube formation from myoblasts relate to the sarcomere structure & myofibrils? How do these link?

14 April 2022 0 271 Report

So from my understanding here are two processes of the formation/growth/repair of skeletal muscle:

Myosatellite cells differentiate into myoblasts, which are proliferating. when the differentiation process starts, they align and fuse to form primary myotubes. These myotubes then fuse with other myoblasts to form larger secondary myotubes, which then become myofibers?

Myofibrils, which make up the muscle fascicle, have sarcomere structures all over them (with all the various bands, eg actin and myosin filaments).

But my question is how do these structures actually link to each other? How do myoblasts growing and differentiating turn into myofibrils with sarcomeric structures?

I haven't seen any articles/papers explicitly linking and when I google it I get so many mixed and different answers.

If you could provide an explanation, or a paper/website clearly explaining this, I would greatly appreciate it.

Thank you very much in advance.

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