Dr. Szent-Gyorgyi was more than a pioneer of biochemistry -- he was
a " father " of biochemistry. He was awarded the Nobel Prize in
Medicine in 1937 for his discovery of the biological oxidation
process with special regard to vitamin C and fumaric acid catalysis.
In 1928 he isolated what he at first called " hexuronic acid, " but is
now called " ascorbic acid " or vitamin C.
He also " discovered " the muscle protein actin, actomyosin and their
relationship to ATP.
He discovered the C4 dicarboxylic acid catalysis that forms the
basis of the Krebs cycle which was pioneering research on how food
is converted into energy.
His keen mind and bright ideas opened the doors to many areas of
biochemical research. He taught us so much, yet he was often labeled
a " maverick " because of his new ideas.
Dr. Szent-Gyorgyi always professed that his discovery of the
biological function of bioflavonoids was serendipitous.
He found something he did not seek.
While he was trying to isolate vitamin C, his colleague Professor
I. (St.) Rusznyak had a patient with subcutaneous capillary
bleedings.
They thought that vitamin C might help, so they gave the patient an
impure preparation that contained vitamin C plus other compounds.
They achieved a rapid success.
Later, a similar patient was treated with a pure solution of
vitamin C expecting quicker success,but instead, the pure solution had NO effect.
So they went back to the impure solution.
Dr Szent-Gyorgyi suspected that a flavone might be the key factor.