How does the human microbiome influence health and disease, including implications for personalized medicine and microbiome-targeted therapies?

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Loubna Youssar

The human microbiome (known as second brain) profoundly influences health and disease by affecting digestive function, immune system modulation, metabolic processes, and mental health, with imbalances linked to conditions like IBS, diabetes, and even cancer. Personalized medicine leverages microbiome profiling to tailor dietary recommendations, probiotics, and other therapies to individual needs, while microbiome-targeted therapies such as fecal microbiota transplantation and specific prebiotics or probiotics aim to restore or enhance microbial balance for improved health outcomes. This approach promises more precise and effective treatments by aligning interventions with each person's unique microbiome composition.