why do i get asterisks in gridpoint 2? i am new to this ONIOM topic. it is a single point energy calculation, where in the high layer there are 18 residues and a ligand, and in the low layer the rest of the enzyme.
ONIOM: gridpoint method 1: low system: model energy: 6.056781229395
ONIOM: gridpoint 2 method: high system: model energy: ******************
ONIOM: gridpoint method 3: low system: real energy: 29.725408826125
ONIOM: extrapolated energy = -10162.782334592475