What is the relationship between the elongated structure of cells during in vitro culture in incomplete media (media without serum) and its slow growth kinetics?
I guess the file in attachment might be helpful for you.
Usually cells differentiate without serum, leading to a more elongated structure. Serum has different growth factors which contribute to increased cell proliferation, therefore cells will grow more slowly without serum .
Thanks to both the replies. But I am not very clear still in understanding the elongated morphology in absence of serum, though slower growth rate can be correlated with the same. However those same cells when again grown in serum complemented media, regains its original morphology. With very less or no growth supplements, why do cells become elongated and how elongated structure selectively provide advantage if any in serum free media?
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