Thanks.

Actually this is related to my dissertation topic. Well many researchers reported that a correlation exist between metal tolrence and antibiotic resistance in bacteria because of the likehood that resistance genes to both may be located on the same plasmid in bacteria.

But i need something more information about it.

thanks,

for the information about MDR efflux system.(Efflux as a mechanism of resistance to antimicrobials in Pseudomonas aeruginosa and related bacteria: unanswered questions)

i found that MDR mechanism is due to the sequential accumulation of chromosomal mutation in different drug resistance genes, as in the case of MDR-TB.

do you have something information about the mechanism in detailed. i need to know more about it............. :-)

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Hello Gabriele ,

yes i am not only talking to MDR efflux system. it is just a point related to my research topic. actually my main concern on heavy metal resistance property in bacteria isolated from tannery effluent. but actually from pathogenic point of view study of antibiotic resistance bateria is also important that is related to heavy metal resistance.because both the properties affect our environment and human health.

but anyways thanks for articles, papers and time that you given to me................

In addition to MDR efflux systems, it is now confirmed that the resistance genes for some antibiotics and heavy metals occur together and are both plasmid mediated. Taking this in mind then possibilities for cross resistance between antibiotics and heavy metals exists. You may opt to check this article also; Berg et al 2010. Env Sci Technol 44: 8724‐28

Hello,

Because they are normally part of integrons and transposons, including in a single cassette resistance genes to antibiotics and heavy metals. When the bacteria resistant to one of these antibiotics is selected using the antibiotic (selective pressure) also resistance to heavy metals is selected, and conversely, when bacteria is exposed to heavy metals, strains resistant to antibiotics are selected. An example: Class 1 integrons in benthic bacterial communities: abundance, association with Tn402-like transposition modules and evidence for coselection with heavy-metal resistance. Rosewarne CP, Pettigrove V, Stokes HW, Parsons YM. FEMS Microbiol Ecol. 2010 Apr;72(1):35-46. Epub 2009 Dec 2.

You can seach in PubMed, with integrons or transposon and mercury resistance as example. Integrons or transposons could be also in the bacterial chromosome