How do I take care of mice recovering from ICV injection for subsequent behavioral tests?

03 April 2015 1,796 5 View

What's the purpose of acetylation for amyloid beta peptides?

I've been searching for suitable amyloid beta peptides to induce Alzheimer's disease related symptoms in cells and mice. Some of the peptides are being acetylated on one end, which "may improve...

01 February 2015 392 6 View

What are the mortality rates like for APP/PS1dE9 Tg mice on a C57BL/6 background?

11 December 2014 1,009 6 View

How should one choose a gender for mouse behavioral tests and sexual dimorphism in 3xTg-AD mouse model?

It has been suggested that AD is more common in human female population and disease progression is more aggressive in female 3xTg mouse model. However 3xTg males seem to be used quite often in...

09 October 2014 850 7 View

What are the effects of fear conditioning and the Morris water maze on mouse

I'm planning to do fear conditioning and a Morris water maze on mice in my experiment, but both tests seem to be stressful for animals. Would these two tests interfere with each other? If it's ok...

09 October 2014 9,282 4 View

Does anyone have experience with Tg CRND8 mouse model for Alzheimer's Disease?

08 September 2014 9,220 3 View

Why does there seem to be few Alzheimer's Disease research with inducible mouse models?

I've been looking for a mouse model for AD research, an inducible model would be most suitable for the original experiment design. I found a few Jackson tetO transgenic models, but there seems to...

08 September 2014 1,390 7 View

Does anyone have experience with APPswe/ PS1dE9 mouse model for cognitive tests?

I'm trying to fix a mouse model for AD cognitive research. It's suggested that APP/PS1dE9 model is suitable and commonly used for cognitive research. I'm not sure exactly what the reasons are...

08 September 2014 1,937 1 View

Why does blocking with my immunogenic peptide cause nuclear fluorescence in ICC?

Hi all, I am validating a polyclonal antibody raised against human ANT4, through WB and ICC. In most of my controls, the antibody shows very little off-target binding, but when I pre-incubate the...

03 March 2021 5,999 3 View

Anyone plz suggest relevant topic for research in image processing+Deep learning.?

I have selected brain tumor images ...but now found that already lots of research done n this topic.

03 March 2021 5,774 3 View

How to repeat an operation on an atom selection for multiple times in PyMol?

Hi, I am trying to construct a multi-layer fibril structure from a single layer in PyMol by translating the layer along the fibril axis. For now, I am able to use the Translate command in PyMol...

02 March 2021 4,569 4 View

What analysis to choose with a large neste dataset and clearly skewed or kurtotic distributions?

Hello! I have a dataset of n=3000 nested within 8 countries with approximately 200 or 400 responses in each country. I originally planned to perform multilevel modelling with 4 dependent variables...

02 March 2021 6,865 1 View

What kind of food stuff increase the potentiality of human brain?

There are different kinds of food stuffs which we intake daily according to our requirements. Carbohydrate, protein, fat, mineral, vitamin, water are mainly working for the growth and development...

01 March 2021 831 2 View

Any specific pipeline or parameter to analyse total transcriptomics study of brain tissue samples?

I have two groups of brain samples, control and treated for example. It was total RNA nova seq sequencing. I tried all the available pipeline like: star+rsem+deseq2, Hista+stringtie+cuffdiff,...

27 February 2021 356 6 View

Can Ethovision store the generated data and video recordings directly to NAS system?

The size of data generated by Ethovision is huge. Having NAS system for data storage seems to be a good option, I am wondering whether Ethovision can directly store the data to the NAS system...

27 February 2021 6,350 2 View

How to plot the probability paper of Gumbel distribution using R programing?

In R-studio, there are many commands of Gumbel package. Arguments are also different. I`m asking about the alpha parameter of the Copula which must be greater than 1. If this is the one used to...

25 February 2021 5,229 3 View

How to handle studies which report perfect effect sizes in a meta-analysis using Pearson's r?

I'm in the process of updating a meta-analysis and in one of the new studies, effect sizes are reported as Tau-U. Two of the effect sizes are reported as Tau-U = 1.00. I am using Andy Field's...

24 February 2021 2,265 3 View

Can MicroRNA cross the blood brain barrier?

In diseased conditions, many genes and gene products are visible in the bloodstream. So my question is whether we can find traces of microRNA which is involved in disease and disorder in blood serum?

24 February 2021 7,064 3 View