Lin Zhou

9 Questions 10 Answers 0 Followers

Questions related from Lin Zhou

How do I take care of mice recovering from ICV injection for subsequent behavioral tests?

Hello: I'm planning to do ICV injection on mice (with amyloid-beta peptides for Alzheimer's disease), the dosage should be somewhere around 3µL. I'm not sure if the procedure would cause too much...

04 April 2015 1,817 5 View

Which is the better site of injection and vehicle for Amyloid-beta?

Hi, I'm trying to inject A-beta 25-35 for my mouse (C57BL/6) and it looks like mostly ddH2O is used for solvent in previous studies. I wonder how I can choose proper solvent for A-beta, why not...

04 April 2015 8,482 2 View

What's the purpose of acetylation for amyloid beta peptides?

I've been searching for suitable amyloid beta peptides to induce Alzheimer's disease related symptoms in cells and mice. Some of the peptides are being acetylated on one end, which "may improve...

02 February 2015 418 6 View

What are the mortality rates like for APP/PS1dE9 Tg mice on a C57BL/6 background?

I've got some APP/PS1dE9 Alzheimer's disease Tg mice on a C57B/L6 background, which is not recommended on the Jax website because of increased mortality rates and seizures. The original strain...

12 December 2014 1,031 6 View

How should one choose a gender for mouse behavioral tests and sexual dimorphism in 3xTg-AD mouse model?

It has been suggested that AD is more common in human female population and disease progression is more aggressive in female 3xTg mouse model. However 3xTg males seem to be used quite often in...

10 October 2014 870 7 View

What are the effects of fear conditioning and the Morris water maze on mouse

I'm planning to do fear conditioning and a Morris water maze on mice in my experiment, but both tests seem to be stressful for animals. Would these two tests interfere with each other? If it's ok...

10 October 2014 9,304 4 View

Why does there seem to be few Alzheimer's Disease research with inducible mouse models?

I've been looking for a mouse model for AD research, an inducible model would be most suitable for the original experiment design. I found a few Jackson tetO transgenic models, but there seems to...

09 September 2014 1,412 7 View

Does anyone have experience with APPswe/ PS1dE9 mouse model for cognitive tests?

I'm trying to fix a mouse model for AD cognitive research. It's suggested that APP/PS1dE9 model is suitable and commonly used for cognitive research. I'm not sure exactly what the reasons are...

09 September 2014 1,958 1 View

Does anyone have experience with Tg CRND8 mouse model for Alzheimer's Disease?

I'm trying to fix a mouse model for my AD experiment which involves multiple cognitive tests at different stages of the disease. It was mentioned that a considerable amount of CRND8 models don't...

09 September 2014 9,242 3 View