MicroRNAs are a class of post-transcriptional regulators. They are short ~22 nucleotide RNA sequences that bind to complementary sequences in the 3’ UTR of multiple target mRNAs, usually resulting in their silencing. MicroRNAs target ~60% of all genes, are abundantly present in all human cells and are able to repress hundreds of targets each.
MIRNA-DISTILLER:
http://www.ikp-stuttgart.de/content/language1/html/10415.asp
There are several softwares out there, none of them are perfect, but can provide an overview of potential targets. Real targets are likely to be a subset, depending on specific expression in tissue/cell of interest, as well as sponge effect of other RNAs, and UTR shortening effects.
http://www.targetscan.org/
http://pictar.mdc-berlin.de/
http://diana.cslab.ece.ntua.gr/ (allows also integration of expression data)
http://cometa.tigem.it/ (also incorporating expression data)
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- Biological Science
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- microRNA