15 Questions 56 Answers 0 Followers
Questions related from Maria Thomas
As far as I understand, without a working version of ACE2, SARS-CoV-2 is essentially locked out of a person's immune system. Are there already some tests available on genetic forms of ACE2 that...
18 October 2020 3,306 2 View
Does anyone have an experience in performing or establishing such tests? Obviously, standard paternity tests will not work in this case. I have found that currently novel technologies enable...
23 October 2019 4,707 3 View
Thank you for any input!
11 July 2016 424 2 View
Could someone share his/her experience in using SOMAmers (Slow Off-rate Modified Aptamer) reagents in detecting the same protein using Aptamers or antibodies? Thank you!
10 November 2015 3,960 0 View
I wanto to order splice-switching oligonucleotide which should target pre-mRNA and force/induce exon skipping to be used in human cells in cell culture experiments. Which backbone (DNA or RNA) and...
20 January 2015 5,569 9 View
Thank you.
19 December 2014 9,490 4 View
Since the first report in 1997 it is known that the chicken anemia virus protein, apoptin, induces apoptosis specifically in human transformed and malignant cells but not in normal cells. There...
17 March 2014 2,131 23 View
We´ve got data strongly indicating that TF regulates the gene of interest via direct binding within an intron and not in the promoter region. How can I prove the functional activity of such a...
13 January 2014 7,670 28 View
And how?
23 July 2013 8,872 3 View
Is anyone aware of a commercially available "nutraceuticals" - compound library for screening in the cell lines?
13 May 2013 2,973 4 View
We apply successfully a ChIP - Sybr-Green method in our group for analysis of TF binding enrichment within single promoters. Can one apply ChIP-Seq approach not for a genome-wide analysis but only...
30 April 2013 4,129 19 View
I would very appreciate to get some hints and relevant references on the examples of physiological control of kinetic coupling during alternative splicing.
25 April 2013 8,174 1 View
Does anybody know a resource for the concentrations of different antibiotics (like Hygromycin, Blasticidin, G418 etc) which should be used for the generation of stable clones in different cell...
13 February 2013 1,492 9 View
Is the knowledge of forensic DNA typing so far advanced that one can simulate a "face" of a person, based only on genetic material? The form of the nose, the distance between eyes, etc? And if...
17 January 2013 6,137 3 View
We had an important discovery: PPARα directly regulates expression and activity of CYP3A4, the major drug metabolizing P450 enzyme in humans. (Klein et al, CPT, 2012; Thomas et al, Mol Pharmacol,...
14 January 2013 3,339 3 View
