According to the WHO report, Cutaneous Leishmaniasis is caused by L. infantum, L. tropica, L. major, L. aethiopica and L. donovani.
But L. donovani usually cause Visceral Leishmaniasis.
The most common cutaneous leishmaniasis causative agents are L. tropica and L. major.
Which are the genes responsible for clinical manifestations caused by various species of Leishmania.
Anybody have some idea?
Dear Sir it could be related in some what with following quotation :
Amastigotes of L. donovanienter macrophages via a Rac1- and Arf6-dependent process, and are found in phagocytic vacuoles that interact with endosomes and lysosomes and acquire lysosomal features.[39] During phagocytosis by macrophages, the promastigotes inhibit the formation of the phagolysosome, a cellular product by which invading pathogens are removed. The promastigote can do this using its glycolipid lipophosphoglycan (LPG) on its cell membrane.
http://en.wikipedia.org/wiki/Leishmania_donovani
I think that the answer to your question is not straightforward. Besides the role played by the aetiological agent, Leishmania spp and the common tropism (visceralizing, cutaneous, muocutaneous) a wide range of situations have been described. For instance, L.infantum, a generally visceralizing agent, also provokes cutaneous lesions. For sure the immune system of the host also plays a fundamental role on the final outcome of the disease. Perhaps your questions should be reformulated.
As Jose mentioned, is a difficult question to answer. First I would say the course of the infection is multifactorial and depends on vector, host and parasite factors, therefore is difficult to assign just to a particular set of genes in the parasite the fate of the infection. The completion of the genome sequence and annotation of several leishmania species has highlighted the presence of some genes that seem to be specific of visceral species. Also the A2 gene family seems to be important for visceralization. You can check the following review that summarizes vector, host and parasite factors that might be important to determine the course of the infection.
Article Determinants for the Development of Visceral Leishmaniasis Disease
it is so complicated... check the following review; you can have some answers
The past, present, and futur of Leishmania genomics and transcriptomics. Cinzia Cantacessi et al, 2015, Trends in Parasitology:
- Badges
- Science topic
- Similar topics
- Biological Science
- Molecular Cell Biology
- Culture Cells
- Cell Line