Pretreatment with anthracyclines may induce BCRP (ABCG2) in 231 cells. Another way is to exogenously express BCRP in these cells to test their drug resistance.
As the level of BCRP grows in breast cancer (and is a prognostic indicator), its inactivation can be performed (uncontrolled) viruses, and controlled - sulforaphane, lapatinib (inhibits transport proteins BCRP and OATP1B1) memorativa
(Valid for cell lines:AGS; HT-29; and breast cancer MCF-7 and MDA-MB-231) Data obtained using the MTT-test)