I am formulating an herbal topical cream for nerve pain. Herbal extracts and essential oils with traditional use and formal data support are included. I wanted to include a B-complex for nerve health (I know that dietary B vitamins are the most effective but as this project is topical-only, I wanted to include it with the aim that it would have some additive action to the botanicals). However, I am not sure how dosing works topically. If I have a 1 ounce cream, how many Mg of B complex liquid would I add?
I am still in the trial stages, I may not end up including it at all but I want to make one with B complex and one without it and compare to see if there is any significant difference in the analgesic effects of both topicals.
Topical absorption is very difficult to anticipate. It depends on the form of the vitamin or product, the patients curculation etc. my rule of thumb is keep to tge maximum systemic does assuming 100% absorption. Then you cant over dose. My favourite combo for nerve pain in Hypericum perforatum tincture (as much as you can combime) and Capsicum annuum thincture, the latter at a dilution of 0.1% with your base cream. Wait ten days for full effect and then consider increasing the prportion of chilli to 1%. Avoid contact with eyes, nose, mucous membranes and warn the patient to avoid hot showers and baths for several hours sfterwards. Good luck in your project
According to LD50 , efficacy and kinetic results using different concentrations
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