Hmm..that's an interesting question. It will be good to know how dependent on blood transfusion the patient is.Is it daily,weekly,monthly,quarterly etc?

It^s not easy to answer this question. I think as Francis does that depends on how frequently the patient is transfused.

thanks alot Francis and Nilo

 the majority of the patients receive transfusion once every 4-6 weeks

Hi, if you take a blood sample over the 4-6 weeks post-transfusion, you have a lot of donor¨s cells circulating, incluiding lymphocytes.

Hello Noha,

I think it is also important to know the miRNa signature in the source blood as well.

Our concept of miRNA and its role in diseases took a major turn when we found that alien miRNAs can also survive in our system. If you have the time kindly read the attached manuscript. It will interest you.

Warm regards,

Venk

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