There has been a widespread emergence of antibiotic resistance across microbial communities including both pathogens and nonpathogens. Apparently, the ability to develop resistance is in-built in the genetic machinery of the microbes as they needed to protect themselves during the course of evolution. This implies that resistance will emerge against an antibiotic from microbes sooner or later. Thus there appears to be need to look into the perpetual emergence of antibiotic resistance in microbes and its remedies.
Post antibiotic era will have new interface and new revolution....like Mr. Chintamani said that resistance can be of different types and can be harsh when it comes multiple drug resistance (MDR).
But as the new approach of drug discovery project are working out, very soon we are in, a era of better drugs against these concerning problem.
Drug discovery approaches like MDL approach, hybrid approach, where a single ligand (drug) is designed for the 2 or more than 2 targets, surely decrease the chances of resistance.
However, many novel targets are being discovered or still in the way to be discovered, which will provide rationality to the antibiotic chemotherapy.
Conclusively, I would say that definitely resistance pose a challenge but then only it give a chance for research to begin.
Here i am adding a latest paper related to the novel target in leishmaniasis. Follow the link
https://www.researchgate.net/publication/248382055_Cystathionine__Lyase_like_Protein_with_Pyridoxal_Binding_Domain_Characterized_in_Leishmania_Major_by_Comparative_Sequence_Analysis_and_Homology_Modelling
Article Cystathionine β Lyase like Protein with Pyridoxal Binding Do...
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