I am moving into a new, essentially empty laboratory space. I plan to set up PCR reactions for amplicon sequencing in that laboratory space and I am concerned about contamination from amplicons, clones and other DNA products from people who may have inhabited the space before me. I am trying to figure out what a suitable cleaning approach would be to remove any trace DNA from all laboratory surfaces.

I had been contemplating spraying down every surface with a decontaminating solution, essentially a mix of bleach and alcanox, described here http://pipettejockey.com/2016/05/06/make-your-own-nucleasenucleic-acid-decontaminating-solution. Its essentially a a home made DNA/RNA/DNAse/RNAse cleaner like DNA away or RNAse away. Its essentially a mix of bleach, alcanox, and bicarbonate. I am wondering if this approach would be effective and useful, ineffective, or perhaps counterproductive.

Once concern that I had with such an approach would be that perhaps residual bleach effects form the bleach in the cleaner to interfere with any sort of microbial growth experiments that we might do in the same space. I know I don't clean plastic-ware with bleach for this reason, but maybe its not such a concern for surfaces, since my samples do sit inside plasticware, but don't sit on surfaces.

Thoughts? I don't know that I have an amplicon contamination problem at this time, I'm just trying to be proactive here. Also I need to clean everything anyway.