What is the toxicity mechanism of propargylamine?

13 March 2019 1 1K Report

Propargylamine (AKA 2-Propynylamine, 3-Amino-1-propyne) is a liquid which carries the hazard statement H310: "Fatal in contact with skin".

With a dermal LD50 of 66 mg/kg in rats, the hazard statement is obviously true. However, I fail to find the mechanism of action for this toxin.

Terminal alkynes seem relatively non-toxic. Primary aliphatic amines do seem toxic, but not nearly as much (dermal LD50 of the alkane equivalent, propylamine, is 403 mg/kg).

Does anyone know what the mechanism of acute toxicity is for this compound?

Tomasz Grabowski

Dear Oded Rimon,

Propargylamines are inhibitors of type B monoamine oxidase. Moreover benzylpropargylamine , and pargyline N-oxide in vivo can decompose to hepatotoxic acrolein.

Please find links for papers partially answering your question:

Article Site-Specific protein propargylation using tissue transglutaminase

Article Donepezil + propargylamine + 8-hydroxyquinoline hybrids as n...

Article Studies on endogenous toxins as pathogenic factors in idiopa...

Article Aliphatic N-methylpropargylamines as potential neurorescue agents

Article Neurochemical, neuroprotective and neurorescue effects of al...

Best regards

Tomasz

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