What is the relationship between sumoylation and deacetylation? Do they compete in inhibition or promote each other?
Ubiquitin is a polypeptide that attaches covalently to poteins, marking them for destruction. SUMOs are Small Ubiquitin-related MOdifiers that, like ubiquitin, attach covalently to proteins (sumoylation) but do not mark them for destruction. Instead they modify the way the protein interacts with other proteins and with cellular systems. Removal of the polypeptide (desumoylation) is described in http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923543/.
Acetylation is the addition of an acetyl (CHs-C=O) group to another molecule.and decatelyation is the removal, of an acetyl group, chemically or, in biological systems, by an enzyme (an acylase). Choline is converted to acetylcholine (ACh), a neurotransmitter that activates muscle. Acetylcholinesterase (AChE) removes the acetyl group and inactivates the neurotransmitter when its job is done. AChE inhibitors (AChEI) prolong the life and effect of ACh. In normal people they can be very toxic and cause paralysis. (http://en.wikipedia.org/wiki/Acetylcholinesterase_inhibitor)
If you are a biochemist you will know all this already. If not, why are you asking?
You can easily find this information by entering he right words in Google. Just as I have done!
All very interesting (and condescending) Stephen, but you didn't actually answer the question. All you gave is some sort of 'definition' of each and not a very pertinent one in the case of acetylation.
There are definitely functional links between the two, for example:
http://www.ncbi.nlm.nih.gov/pubmed/25425577
http://www.ncbi.nlm.nih.gov/pubmed/25294883
and acetylation can apparently influence the SUMOylation apparatus:
http://www.ncbi.nlm.nih.gov/pubmed/23395904
but off the top of my head, I can't think of a good example where the same lysine competes for either acetylation or SUMOylation within the same target protein. I'd be surprised if it doesn't occur though.
Simon
You are right . It does sound condescending, which is not at all what I intended. I asked out of curiosity, not arrogance. I visualised the remarks accompanied by appropriate non-verbal signals (a smile, raised eyebrows). I apologise to anyone who found the bald statement offensive!
Your refs are interesting. Obesity and diabetes are not my field but I am interested in PD And AD ( I have the disordered-speech dominant, non-tremulous Parkinson's Spectrum Disorder and so have an interest in conformational illnesses in general).
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